When you use it for the first time:

IMPORTANT – This is a concentrated and powerful serum. As with any skincare product, we suggest doing a Patch Test on a small area of skin on your neck to make sure the formula is a good fit for you. Once you determine there is no problem with the patch test you should (1) Wash your face and then dry (2) Apply a small amount to your entire face, neck and decollete, (3) allow to dry (4) Follow with a moisturizer.